Control:Article Title: FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies FBXO3(CO-IP) Santa Cruz Cat# sc-514625; RRID: AB_3713047 GAPDH Servicebio Cat#GB12002; RRID: AB_3206256 FBXO3(WB) Proteintech Cat#17803-1-AP; RRID: AB_2278445 PARP1 Proteintech Cat#13371-1-AP; RRID: AB_2160459 Caspase-3 Proteintech Cat#19677-1-AP; RRID: AB_10733244 Cleaved caspase-3 Cell Signaling Technology Cat##9661; RRID: AB_2341188 BCL-xL Proteintech Cat26967-1-AP; RRID: AB_2880702 BCL-2 Proteintech Cat#12789-1-AP; RRID: AB_2227948 MCL-1 Proteintech Cat#16225-1-AP; RRID: AB_2143977 BAX Proteintech Cat#50599-2-Ig; RRID: AB_2061561 BAD Proteintech Cat#10435-1-AP; RRID: AB_2061994 XIAP Proteintech Cat#10037-1-Ig; RRID: AB_2215009 Survivin Proteintech Cat#10508-1-AP; RRID: AB_2064048 Cytochrome c Proteintech Cat#10993-1-AP; RRID: AB_2090467 DUSP9 ABclonal Cat#A3839; RRID: AB_2765337 HA Proteintech Cat#51064-2-AP; RRID: AB_11042321 FLAG ABclonal Cat#AE005; RRID: AB_2770401 MYC proteintech Cat#60003-2-Ig; RRID: AB_2734122 Mouse mAb IgG1 Isotype control Cell Signaling Technology Cat##5415; RRID: AB_10829607 p44/42 MAPK (Erk1/2) Cell Signaling Technology Cat##4695; RRID: AB_390779 Phospho-p44/42 MAPK (Erk1/2) (Thr202/ Tyr204) Cell Signaling Technology Cat##4370; RRID: AB_2315112 p38 Cell Signaling Technology Cat##9212; RRID: AB_330713 Phospho-p38 MAPK (Thr180/Tyr182) Cell Signaling Technology Cat##4511; RRID: AB_2139682 JNK Cell Signaling Technology Cat##9252; RRID: AB_2250373 Phospho-JNK1-T183/Y185+JNK2-T183/ Y185+JNK3-T221/Y223 ABclonal Cat#AP1337; RRID: AB_3697809 ASK1 ABclonal Cat#A12458; RRID: AB_2759301 Phospho-ASK1-S1033 ABclonal Cat#AP0058; RRID: AB_2771298 MKK3/MKK6 ABclonal Cat#A19830; RRID: AB_2895227 Phospho-MKK3-S189+MKK6-S207 ABclonal Cat#AP1512 MKK4 ABclonal Cat#A14781; RRID: AB_2861707 Phospho-MKK4-S257/T261 ABclonal Cat#AP0541; RRID: AB_2771289 MKK7 ABclonal Cat#A12950; RRID: AB_2861679 Phospho-MKK7 (Ser271/Thr275) Polyclonal antibody Proteintech Cat#29199-1-AP; RRID: AB_2918246 BIM/BCL2L11 Polyclonal antibody Proteintech Cat#22037-1-AP; RRID: AB_2878978 Phospho-Bim (Ser69) (D7E11) Rabbit mAb Cell Signaling Technology Cat4585; RRID: AB_2065176 Phospho-Bim (Ser77) (D4H12) Rabbit mAb Cell Signaling Technology Cat#12433; RRID: AB_2797911 PE-Cy7 CD34 BioLegend Cat#128618; RRID: AB_2721678 BV421 lineage BioLegend Cat#133311; RRID: AB_11203535 APC-Cy7 Ly6A/E(Sca-1) BioLegend Cat#108126; RRID: AB_10645327 APC CD117(c-Kit) BioLegend Cat#105812; RRID: AB_313221 PE CD135 BioLegend Cat#135306; RRID: AB_1877217 (Continued on next page) Cell Reports Medicine 7, 102686, March 17, 2026 e1 .. REAGENT or RESOURCE SOURCE IDENTIFIER BV605 CD48 BioLegend Cat#103441; RRID: AB_2650825 PerCP/Cy5.5 CD150(SLAM) BioLegend Cat#115921; RRID: AB_2206887 BV510 CD16/32 BioLegend Cat#156625; RRID: AB_3083139 BV711 CD127(IL-7Ra) BioLegend Cat#135035; RRID: AB_2564577 BV421 CD41 BioLegend Cat#133912; RRID: AB_2650893 PE-Cy7 CD34 BioLegend Cat#128618; RRID: AB_2721678 PE-Cy7 CD16/32 BioLegend Cat#156610; RRID: AB_2800708 APC-Cy7 Scal1 BioLegend Cat#108126; RRID: AB_10645327 APC CD117 BioLegend Cat#105812; RRID: AB_313221 Percp Cy5.5 CD71 BioLegend Cat#113816; RRID: AB_2565482 BV421 CD3 BioLegend Cat#100227; RRID: AB_10900227 BV421 CD11b BioLegend Cat#101235; RRID: AB_10897942 BV421 CD11c BioLegend Cat#117329; RRID: AB_10897814 BV421 CD19 BioLegend Cat#115537; RRID: AB_10897814 BV421 Ly6G BioLegend Cat#127628; RRID: AB_2562567 BV421 Ter119 BioLegend Cat#116234; RRID: AB_2562917 BV421 B220 BioLegend Cat#103239; RRID: AB_10933424 BV421 CD49b BioLegend Cat#108918; RRID: AB_2265144 APC-Cy7 CD11b BioLegend Cat#101226; RRID: AB_830642 APC-Cy7 Gr-1 BioLegend Cat#108424; RRID: AB_2137485 APC-Cy7 CD45 BD Biosciences Cat#557659; RRID: AB_396774 Biological samples Individuals with CML and healthy adult donors’ peripheral blood or bone marrow samples The first affiliated hospital of Zhengzhou University/Affiliated cancer hospital of Zhengzhou University N/A Chemicals, peptides, and recombinant proteins Fetal Bovine Serum Gibco Cat#A3160902 Phosphate Buffered Saline Servicebio Cat#G4202 Opti-MEM medium Gibco Cat#11058021 Puromycin Solution (10mg/mL) Biosharp Cat#BL528A Polybrene(10mg/mL) Solarbio Cat#H8761 Recombinant human SCF Peprotech Cat#300-07 Recombinant human IL-3 Peprotech Cat#200-03 Recombinant human IL-6 Peprotech Cat#200-06 Recombinant human GM-CSF Peprotech Cat#300-03 BC1215 Selleck Cat#S3022 Imatinib MCE Cat#HY-15463 CellTrace CFSE Invitrogen Cat#C34554A 5-Fluorouracil MCE Cat#HY-90006 Recombinant mouse SCF Peprotech Cat#250-03 Recombinant mouse IL-3 Peprotech Cat#213-13 Recombinant mouse IL-6 Peprotech Cat#216-16 Protein A/G Plus-Agarose Santa Cruz Cat#Sc-2003 S Protein Agarose Beads Merck Cat#69704-4 MG132 Sigma Aldrich Cat#M8699 CCK-8 Servicebio Cat#G4101 Cycloheximide (CHX) Aladdin Cat#C112766 Critical commercial assays FastPure Cell/Tissue Total RNA Isolation Kit V2 Vazyme RC112-01 (Continued on next page) e2 Cell Reports Medicine 7, 102686, March 17, 2026
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